Novel thermosensitive poly (N-isopropylacrylamide-co-vinylpyrrolidone-co-methacrylic acid) nanosystems for delivery of natural products.
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چکیده
منابع مشابه
Pulsatile local delivery of thrombolytic and antithrombotic agents using poly( N-isopropylacrylamide-co-methacrylic acid) hydrogels
Hydrogels of poly(N-isopropylacrylamide-co-methacrylic acid) were synthesized and investigated as pHand temperature-triggered delivery devices for antithrombotic agents. For hydrogels containing greater than 75 tool% N1PAAm, the pH and temperature sensitivity both influenced the overall swelling behavior of the networks. Streptokinase and heparin were loaded into these hydrogels and their relea...
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Poly(N-isopropylacrylarnide-CO-methacrylic acid) P(NIPArn/MAA) nanoparticles were investigated as potentiai targetable systems for intravenous drug delivery. The responsive properties of P(NIPAm/MAA) nanoparticles have been characterized using dynamic light scattering (DLS) and responsive adhesion techniques. The hydrodynamic diameter of the nanoparticles decreased with increasing temperature o...
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A novel polymer-modified thermosensitive liposome (pTSL) was developed for the delivery of Doxorubicin (DOX) for cancer therapy. Copolymers containing temperature-responsive N-isopropylacrylamide (NIPAAm) and pH-responsive propylacrylic acid (PAA) were synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization, yielding copolymers with dual pH/temperature-dependent p...
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The effects of the monomer ratio, surfactant, and crosslinker contents on the particle size and phase-transition behavior of the copolymer poly(N-isopropylacrylamide-co-methacrylic acid) (PNIPAAm–MAA) were investigated with Fourier transform infrared, differential scanning calorimetry, and dynamic laser scattering techniques. In addition to the thermoresponsive property of poly(N-isopropylacryl...
متن کاملAdsorption of Cu Ions with Poly (N-isopropylacrylamide-co-methacrylic acid) Micro/Nanoparticles
Chelation efficiency of stimuli-responsive poly(N-iospropylacrylamide-co-methyacrylic acid) (PNIPAAm-MAA) nanoparticles with Cu ions from CuSO4 5H2O solution and from wood treated with copper-based preservatives was studied. It was shown that particle size played a very important role in the adsorption process. The nano-scale particles showed much improved Cu ion adsorption efficiency, compared...
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ژورنال
عنوان ژورنال: International Journal of Drug Delivery
سال: 2010
ISSN: 0975-0215
DOI: 10.5138/ijdd.2010.0975.0215.02039